4’33’’-Silent Shock

Toxic shock syndrome: a silent killer.

We present a case of a 27-year-old para 2þ 0 who had a normal delivery 2 years previously. She had a previous cone biopsy for CIN3 and was receiving annual smears. She was referred by her GP to our A&E department with a 24 h history of generally feeling unwell, with diarrhoea, vomiting and lower abdominal pain. Her temperature was 388C; she was hypotensive (blood pressure 72/ 38 mmHg), with a r...

Dmd061598 433..443

Active transport of glucuronide out of cells is a critical process in elimination of drugs via the glucuronidation pathway. Here, HeLa cells were stably transfected with UGT1A1 and the contributions of BCRP and MRP family transporters to the cellular efflux of chrysin glucuronide (CG) were determined. The cDNA of UGT1A1 was introduced into HeLa cells using the lentiviral transfection method. Th...

Bez nazwy-433

Pns1300339 433..440

This review aims to assess the efficacy and safety of voluntary fortification as an option to address the occurrence of inadequate micronutrient intakes in population subgroups in Europe. Although legislation is harmonised across the European Union, fortification practices and patterns of consumption of fortified foods vary considerably between countries. While the proportion of children consum...

Npgrj_nm_1390 433..440

Pathological conditions in the central nervous system, including stroke and trauma, are often exacerbated by cerebral edema. We recently identified a nonselective cation channel, the NCCa-ATP channel, in ischemic astrocytes that is regulated by sulfonylurea receptor 1 (SUR1), is opened by depletion of ATP and, when opened, causes cytotoxic edema. Here, we evaluated involvement of this channel i...